一个噬血的连环杀手，在犯下多达300多起滔天罪案之后，至今仍逍遥法外。但是，出于对新闻的渴望，几个美国新闻工作者却敢于冒失去生命的危险，而涉足此地。制片人蒂姆·弗里曼（多米尼克·珀塞尔 饰）、摄影师史蒂文·约翰逊（奥兰多·琼斯 饰）以及几个同行的同事在几个当地的向导的带领下，终于从繁华的都市来到这恍...如隔世般的另一个世界。
非洲的广阔草原与热带的独特地貌是这里独特之处。凶猛的野兽、恶劣的自然条件为他们的探密之路带来不尽的考验。当他们如愿找到传说中的河流和神秘地区之后，一切似乎都在按着蒂姆·弗里曼和史蒂文·约翰逊等人预想的那样发展。于是，几个人尽管经历了几次惊险的离奇事件之后，依然有勇气沿着河流继续向上游探索。但是，随着对神秘之地的越来越深入，致命的危险也越来越靠近这些外来的造访者……
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