俗话说水火无情啊，这不，一场大火就要了伯德莱尔夫妇的命，剩下三个孩子无依无靠。不过这三个小鬼也不简单，14岁的维奥丽特(艾米丽·布朗宁饰)热情大胆，是最年长的，自然也成了三人的头头；12岁的克劳斯(连恩·艾肯饰)机智聪明，经常从脑子里蹦出一些奇怪的主意；桑尼(郝夫曼双胞胎)则实在太小了，她还是个婴儿，而且还有个坏习惯，喜欢撕咬所有她能咬动的东西。幸好，还有一个远亲奥拉夫伯爵(吉姆·凯利饰)愿意收留他们，三人原本以为这下子不用流离失所了吧，可万万没想到苦难的日子才刚刚开始。
原来奥拉夫想谋夺他们的遗产，甚至狠了心制造车祸要杀害三个孩子。他们三人好不容易逃跑后，踏上了万里寻亲之路，可碰到的亲戚一个比一个离谱：蒙蒂叔叔(比利·康纳利饰)还算正常，就是有点迷恋爬行动物，今天脖子上缠个黄色巨蟒，明天抽冷又拽出一条红花小蛇；约瑟芬阿姨(梅丽尔·斯特里普饰)也好不到哪里去，她是一个超级恐惧狂，这回提醒你别乱跑，别绊到地毯跌歪了脖子，下回就告诫你小心吊灯，掉下来要死人啊。
可这毕竟也是个依靠，但无论三个孩子怎么躲避，每一次都被化妆跟踪的奥拉夫找到，给他们带来一系列不幸事件。那他们还能逃出奥拉夫的魔掌吗？要知道反斗小鬼也不是省油的灯，摩登老怪的春秋大梦早晚都会被惊醒。
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