凯西（奥黛塔·雅丝曼饰）是一个二十来岁的妙龄女郎，许多年来，一件事情一直在她心里挥之不去……多年前凯西意外怀孕，她的母亲却让她打掉这个孩子，并且说这个孩子会招来噩运。凯西最后还是坚持把孩子要了下来，但母亲却突然失踪，并且留信给凯西，告诉她无法和这个孩子共存。凯西对母亲的做法感到非常费解，多年来，凯西也在不停地寻找母亲的下落，但总是无功而返。孩子渐渐的长大，凯西却没有感到丝毫的幸福可言，相反的，她却逐渐陷入许多的幻觉与梦靥。在街上和家中，凯西经常看见许多“不干净”的东西……一个长得很像自己儿子的面目阴森的小孩，正满怀着仇视的目光直视着她。而他的孩子也渐渐有着许多不同常人的举动。寻求心里医生的帮助，医生却建议她不要胡思乱想；无奈之下，她只能求助于好友罗密（梅根·古德饰）和男朋友马克（凯姆·吉甘戴饰）。在两人的帮助下，凯西开始调查事情真相，发现这一切都跟一个名叫拉比（加里·奥德曼饰）的男人有关，原来，当年她的母亲曾经和拉比有着一些说不清道不明的事……随着调查的深入，凯西发现整件事情比她想像的要复杂得多，甚至牵扯到数十年前自己的家族与德国纳粹的生化实验，在某次人体实验中，一个小孩在死之前将自己的怨气注进一个诅咒之中，而在死后，这个小孩成为怨灵，他的诅咒开启了异世界的门，如果不将这道门关闭，那么整个世界将毁于一旦。凯西现在面临的，不仅仅是拯救世界，拯救自己的亲生骨肉，她还要拯救整个世界……
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