变性杀手此片包含家人，性认同和谋杀等元素，变性杀手米娅要将她的杀手生活与新的家庭生活融为一体。该剧将由曾获奥斯卡提名的美国性感女星Chloe Sevigny (《好心先生》《男孩别哭》)扮演主角Mia——被地下党老大Eddie（Peter Wright饰演）训练杀人的女杀手。但是Mia有个秘密：她曾经是男人。本来这个秘密可以尘封被忘却，但事情突如其来，11岁男孩Ryan走进了她的生活，而Mia正是他的“爸爸”。因为Mia前女友Wendy（Ryan的母亲）身患癌症，不久后将死去，Mia前去探访Ryan、Wendy和她的其它孩子，一边照顾他们，一边作为门徒面对Eddie，过着双重生活。
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