该剧故事主要聚焦于托马斯·哈里斯的小说《红龙》，主要讲述了汉尼拔和FBI探员威尔·格拉哈姆之间早期的关系。汉尼拔博士是一位著名的精神病学家，而威尔·格拉汉姆则是他的病人，一位年轻的FBI犯罪侧写师。汉尼拔被他对连环杀人犯的移情能力而困扰。
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