态度无礼，表情凶恶，跛足拄着一根藤棍，永远是牛仔裤运动鞋的便装打扮而不是整洁的白大褂，普林斯顿大学附属医院的格雷戈-豪斯从外表与好医生的形象相差甚远，他甚至竭力避免和病人说话，并认为世人皆不可信，至少病人自己所说的病因都是胡扯。虽然豪斯几乎是个愤世嫉俗的反社会论者，他非传统的思维方式和精准无瑕的职业...直觉令他赢得了病人和同僚的一致尊敬。作为一位内科医师，豪斯对解决医学疑难并挽救生命有着无人可比的热情。
The Honeymoon本集依然停留在豪斯的前女友及丈夫身上，豪斯会否用其它的方法治疗她的丈夫，而重新争取Stacy？
Three Stories豪斯的前女友Stacy Warner请求他医治她的丈夫，在这集中，三个丑小鸭了解了些豪斯重要的过去，以及如何成为一个好医生。
Love Hurts本集聚焦在豪斯和Cameron即将到来的约会，案例则是关于一个东方人和不认同他的父母。
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